Best Practices for Effective Tablet Lubrications

Lubricants play a vital role in drug tableting applications; however, they can also produce disastrous results if not fully understood and used carefully. If the drug formulation is under-lubricated, the tablet may be difficult to eject from the die; all or parts of the tablet may stick to the die or punch face. Over-lubrication can affect tablet hardness, extend disintegration times, slow drug dissolution, or even prevent tablets from binding.